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在一篇完整的論文中，完整、清晰的邏輯框架是十分重要的。而這一點(diǎn)又是通過Figure所具體展現(xiàn)。不同的實(shí)驗(yàn)結(jié)果展示成不同的Sub. Figure，闡述共同問題的、核心的Sub. Figures組合成不同的Figure，F(xiàn)igures間按照清晰的邏輯思路構(gòu)建成一篇完整的文章。
圖1 論文中邏輯的構(gòu)建
所以，在論文中應(yīng)該包含兩層意義的邏輯結(jié)構(gòu)：
1 論據(jù)間的邏輯結(jié)構(gòu)——Figure中各個(gè)Sub. Figure的規(guī)劃；
2 論點(diǎn)間的邏輯結(jié)構(gòu)——文章中各個(gè)Figure的規(guī)劃。
對(duì)于論據(jù)間的邏輯結(jié)構(gòu)，這就要求我們選取具有代表性的結(jié)果，通過不同的角度（如，基因、蛋白、細(xì)胞、組織、活體等），層次遞進(jìn)，逐步拓展，探討問題。
圖2 Figure的裝配
而對(duì)于論點(diǎn)間的邏輯結(jié)構(gòu)，除了上述的實(shí)驗(yàn)研究角度，還可以根據(jù)自身研究的通路出發(fā)，對(duì)文章的核心問題展開描述。
以下為相關(guān)的SCI優(yōu)秀文章，以供參考。
Mi-Hwa Kim, Hong-Beum Kim, Sang Pil Yoon, etc. Colon cancer progression is driven by APEX1-mediated upregulation of Jagged.[J] J Clin Invest. 2013 Jul 1. pii: 65521.
Abstract: Aberrant expression of apurinic-apyrimidinic endonuclease–1 (APEX1) has been reported in numerous human solid tumors and is positively correlated with cancer progression; however, the role of APEX1 in tumor progression is poorly defined. Here, we show that APEX1 contributes to aggressive colon cancer behavior and functions as an upstream activator in the Jagged1/Notch signaling pathway. APEX1 overexpression or knockdown in human colon cancer cell lines induced profound changes in malignant properties such as cell proliferation, anchorage-independent growth, migration, invasion, and angiogenesis in vitro and in tumor formation and metastasis in mouse xenograft models. These oncogenic effects of APEX1 were mediated by the upregulation of Jagged1, a major Notch ligand. Furthermore, APEX1 expression was associated with Jagged1 in various colon cancer cell lines and in tissues from colon cancer patients. This finding identifies APEX1 as a positive regulator of Jagged1/Notch activity and suggests that it is a potential therapeutic target in colon cancers that exhibit high levels of Jagged1/Notch signaling.
原文鏈接：http://www.jci.org/articles/view/65521